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Publications

Key publications in specific research areas

Activity-directed synthesis and autonomous molecular discovery

  • G. Karageorgis, S. Warriner and A. Nelson, “Efficient discovery of bioactive scaffolds by activity-directed synthesis”, Nature Chem. 2014, 6, 872-876. Paper
  • G. Karageorgis, M. Dow, A. Aimon, S. Warriner and A. Nelson, “Activity-directed Synthesis with Intermolecular Reactions: Development of a Fragment into a Range of Androgen Receptor Agonists”, Angew. Chem. Int. Ed. 2015, 54, 13538-13544. Paper
  • A. I. Green, F. Hobor, C. P. Tinworth, S. Warriner, A. J. Wilson and A. Nelson, “Activity-directed synthesis of inhibitors of the p53/hDM2 protein-protein interaction”, Chem. Eur. J. 2020, 26, 10682-10689. Paper
  • A. Leggott, J. E. Clarke, S. Chow, S. L. Warriner, A. J. O’Neill* and A. Nelson, “Activity-directed expansion of a series of antibacterial agents”, Chem. Commun. 2020, 56, 8047-8050. Paper
  • G. Karageorgis, S. Liver and A. Nelson,* “Activity-directed synthesis: A flexible approach for lead generation”, ChemMedChem 2020, 15, 1776-1782. Paper
  • S. Chow, S. Liver and A. Nelson, “Streamlining bioactive molecular discovery through integration and automation”, Nat. Rev. Chem. 2018, 2, 174-183.  Paper

Diversity-, lead- and fragment-oriented synthesis

  • D. Morton, S. Leach, C. Cordier, S. Warriner and A. Nelson, “Synthesis of natural product-like molecules with over eighty distinct skeletons”, Angew. Chem., Int. Ed. 2009, 47, 104-109. Paper
  • D. J. Foley, A. Nelson and S. P. Marsden, “Evaluating New Chemistry to Drive Molecular Discovery: Fit for Purpose?”, Angew. Chem. Int. Ed. 2016, 55, 13650-13657. Paper
  • I Colomer, C. J. Empson, P. Craven, Z. Owen, R. G. Doveston, I. Churcher, S. P. Marsden and A. Nelson, “A divergent synthetic approach to diverse molecular scaffolds: assessment of lead-likeness using LLAMA, an open access computational tool”, Chem. Commun. 2016, 52, 5209-5212. Paper
  • D. J. Foley, P. G. E. Craven, P. M. Collins, R. G. Doveston, A. Aimon, R. Talon, I. Churcher, F. von Delft, S. P. Marsden and A. Nelson, “Synthesis and Demonstration of the Biological Relevance of sp3-rich Scaffolds Distantly Related to Natural Product Frameworks”, Chem. Eur. J. 2017, 23, 15227-15232. Paper
  • J. Mayol-Llinas, W. Farnaby and A. Nelson, “Modular synthesis of thirty lead-like scaffolds suitable for CNS drug discovery”, Chem. Comm. 2017, 53, 12345-12348. Paper
  • S. Rice, D. J. Cox, S. P, Marsden* and A. Nelson,* “Efficient unified synthesis of diverse bridged polycyclic scaffolds using a complexity-generating ‘stitching’ annulation approach”, Chem. Commun. 2021, 57, 599-602. Paper
  • A. F. Trindade, E. L. Faulkner, A. G. Leach, A. Nelson* and S. P. Marsden,* “Fragment-Oriented Synthesis: beta-Elaboration of Cyclic Amine Fragments using Enecarbamates as Platform Intermediates”, Chem. Commun. 2020, 56, 8802-8805.  Paper
  • D. Francis, A. Nelson and S. P, Marsden, "Synthesis of β-Diamine Building Blocks by Photocatalytic Hydroamination of Enecarbamates with Amines, Ammonia and N-H Heterocycles", Chem. Eur. J. 2020, 26, 14861-14865. Paper

Directed evolution and biocatalysts

  • A. Berry, S. Domann, A. Nelson and G. Williams, “Modifying the stereochemistry of an enzyme-catalysed reaction by directed evolution”, Proc. Natl. Acad. Sci. USA 100, 3143-3148 (2003). Paper
  • T. Woodhall, G. Williams, A. Berry and A. Nelson, “Creation of an aldolase for the parallel synthesis of sialic acid mimetics”, Angew. Chem., Int. Ed., 2005, 44, 2109-2112. Paper
  • G. J. Williams, T. Woodhall, L. Farnsworth, A. Nelson and A. Berry, “Creation of a Pair of Stereochemically Complementary Biocatalysts”, J. Am. Chem. Soc. 2006, 128, 16238-16247. Paper
  • J. K. Howard, M. Müller, A. Berry and A Nelson, “An enantio- and diastereoselective chemoenzymatic synthesis of alpha-fluoro beta-hydroxy carboxylic esters”, Angew. Chem. Int. Ed. 2016, 55, 6767-6770. Paper
  • C. L. Windle, K. J. Simmons, J. R. Ault, C. H. Trinh, A. Nelson, A. R. Pearson and A. Berry, “Extending enzyme molecular recognition with an expanded amino acid alphabet”, Proc. Natl. Acad. Sci. USA 2017, 114, 2610-2615. Paper

Chemical biology

  • S. Bartlett, G. S. Beddard, R. M. Jackson, V. Kayser, C. Kilner, A. Leach, A. Nelson, P. R. Oledzki, P. Parker, G. D. Reid and S. L. Warriner, “Comparison of the ATP binding sites of Protein Kinases using conformationally diverse bisindolylmaleimides”, J. Am. Chem. Soc. 2005, 127, 11699-11708. Paper
  • H. K. Bone, T. Damiano, S. Bartlett, A. Perry, J. Letchford, A. Nelson and M. J. Welham “Involvement of glycogen synthase kinase-3 in regulation of murine embryonic stem cell self-renewal revealed by a series of bisindolylmaleimides”, Chem. Biol. 2009, 16, 15-27. Paper
  • G. M. Burslem, H. F. Kyle, A. L. Breeze, T. A. Edwards, A. Nelson, S. L. Warriner and A. J. Wilson, “Small Molecule Proteomimetic Inhibitors of the HIF-1a/p300 Protein-Protein Interaction”, ChemBioChem 2014,14, 1083-1087. Paper
  • M. Dow, F. Marchetti, K. A. Abrahams, L. Vaz, G. S. Besra, S. Warriner and A. Nelson, “Modular Synthesis of Diverse Natural Product-like Macrocycles: Discovery of Hits with Antimycobacterial Activity”, Chem. Eur. J. 2017, 23, 7207-7211. Paper

Miscellaneous

  • J. M. Holland, M. Lewis and A. Nelson, “First desymmetrisation of a centrosymmetric molecule in natural product synthesis: Preparation of a key fragment in the synthesis of Hemibrevetoxin B”, Angew. Chem., Int. Ed. 40, 4082-4084 (2001). Paper

Full list of publications

  1. J. Eames, H. J. Mitchell, A. Nelson, P. O'Brien, S. Warren* and P. Wyatt, “An Efficient Protocol for a Sharpless Style Racemic Dihydroxylation”, Tetrahedron Letters, 36, 1719-1722 (1995).
  2. A. Nelson, P. O'Brien and S. Warren,* “Asymmetric Dihydroxylations of Allylic Phosphine Oxides”, Tetrahedron Letters, 36, 2685-2688 (1995).
  3. A. Nelson and S. Warren,* “Intramolecular Acylations of gamma-Benzoyloxy Phosphine Oxides: Synthesis of Optically Active Cyclopropyl Ketones”, Tetrahedron Letters, 37, 1501-1504 (1996).
  4. D. Cavalla, C. Guéguen, A. Nelson, P. O’Brien, M. G. Russell and S. Warren,* “Chiral Phosphine Oxides and Chiral Esters in Stereoselective Intermolecular Acylation Reactions of Phosphine Oxides”, Tetrahedron Letters, 38, 7465-7468 (1996).
  5. A. Nelson and S. Warren,* “Asymmetric Dihydroxylation of Allylic Phosphine Oxides”, J. Chem. Soc., Perkin Trans. 1, 2645-2657 (1997).
  6. J. Clayden, A. Nelson and S. Warren,* “Diastereoselective Reactions of Optically Active g-Substituted Vinyl Phosphine Oxides”, Tetrahedron Letters, 38, 3471-3474 (1997).
  7. A. Nelson and S. Warren,* “Alkenyl Diols by E-Selective Horner-Wittig Elimination: Formal Synthesis of Any Isomer (RR, RS, SR or SS) Bearing 1,5-Related Stereogenic Centres Across an E Double Bond”, Tetrahedron Letters, 39, 1633-1636 (1998).
  8. B. Bartels, C. Gonzalez Martin, A. Nelson, M. G. Russell and S. Warren,* “Asymmetric Addition of a Chiral Lithium Amide to Prochiral Vinyl Phosphine Oxides”, Tetrahedron Letters, 39, 1637-1640 (1998).
  9. J. Eames, H. J. Mitchell, A. Nelson, P. O'Brien, S. Warren* and P. Wyatt, “An efficient protocol for a Sharpless-style racemic dihydroxylation”, J. Chem. Soc., Perkin Trans. 1, 1095-1103 (1999).
  10. B. Bartels, J. Clayden, C. Gonzalez Martín, A. Nelson, M. G. Russell and S. Warren,* “Diastereoselective nucleophilic additions to vinyl phosphine oxides”, J. Chem. Soc., Perkin Trans. 1, 1807-1822(1999).
  11. A. Nelson and S. Warren,* “1,3-Stereocontrol with phosphine oxides: Asymmetric synthesis of all four diastereoisomers of a g’-benzyloxy b-hydroxy phosphine oxide”, J. Chem. Soc., Perkin Trans. 1, 1963-1982 (1999).
  12. A. Nelson and S. Warren,* “Control of remote stereochemistry using phosphine oxides: Formal synthesis of any stereoisomer (RR, RS, SR or SS) of a diol bearing 1,5-related stereogenic centres across an E double bond”, J. Chem. Soc., Perkin Trans. 1, 1983-1998 (1999).
  13. Feeder, G. Hutton, A. Nelson and S. Warren,* “Stereoselective intramolecular acylation of g’-benzoyloxy phosphine oxides with an internal chlorotrimethylsilane trap: isolation of silylated tetrahedral intermediates”, J. Chem. Soc., Perkin Trans. 1, 3413-3424 (1999).
  14. Nelson and S. Warren,* “Stereocontrol with phosphine oxides: synthesis of optically active cyclopropyl ketones”, J. Chem. Soc., Perkin Trans. 1, 3425-3434 (1999).
  15. “Strategies for the stereoselective synthesis of molecules with remote stereogenic centres across a double bond of fixed configuration”, H. J. Mitchell, A. Nelson and S. Warren, J. Chem. Soc., Perkin Trans. 1, 1899-1914 (1999).
  16. “Asymmetric Phase-Transfer Catalysis”, A. Nelson, Angew. Chem., Int. Ed. 38, 1583-1585 (1999).
  17. T. Aftab, C. Carter, J. Hart and A. Nelson, “A method for the stereospecific conversion of 1,3-diols into oxetanes”, Tetrahedron Lett.40, 8679-8683 (1999).
  18. Aftab, C. Carter, M. Christlieb, J. Hart and A. Nelson, “Stereospecific conversion of (1R*,3S*)- and (1R*,3R*)-3-cyclohexyl-1-phenyl-1,3-propanediol into the corresponding 2,4-disubstituted oxetanes”, J. Chem. Soc., Perkin Trans. 1 711-722 (2000).
  19. Green, A. Nelson, S. Warriner and B. Whittaker, “Synthesis and investigation of the configurational stability of some dimethylammonium borate salts”, J. Chem. Soc., Perkin Trans. 1, 4403-4408 (2000).
  20. T. Brain, A. Chen, A. Nelson, N. Tanikkul and E. J. Thomas,* “An approach to the total synthesis of the lankacidins: synthesis of the requisite building blocks”, Tetrahedron Lett.42, 1247-1250 (2001).
  21. Chen, A. Nelson, N. Tanikkul and E. J. Thomas,* “An approach to the total synthesis of the lankacidins: synthesis of advanced macrocyclic precursors”, Tetrahedron Lett. 42, 1251-1254 (2001).
  22. Harding and A. Nelson, “A general, two-directional synthesis of C-(1® 6)-linked carbohydrate mimetics: synthesis from non-carbohydrate-based starting materials”, Chem. Commun. 695-696 (2001).
  23. J. M. Holland, M. Lewis and A. Nelson, "First desymmetrisation of a centrosymmetric molecule in natural product synthesis: Preparation of a key fragment in the synthesis of Hemibrevetoxin B", Angew. Chem., Int. Ed. 40, 4082-4084 (2001).
  24. R. Hodgson, T. Majid and A. Nelson, "Directed and undirected asymmetric dihydroxylation reactions: application in the synthesis of a C-linked analogue of allolactose", Chem. Commun. 2076-2077 (2001).
  25. “Looking in the mirror”, A. Nelson, Chemistry Review, 10, issue 3, 6-9 (2001).
  26. R. Hodgson, T. Majid and A. Nelson, "Towards complete stereochemical control: complementary methods for the synthesis of six diastereoisomeric monosaccharide mimetics", J. Chem. Soc., Perkin Trans. 1,1444-1454 (2002).
  27. R. Hodgson, T. Mahid and A. Nelson, “Desymmetrisation of meso difuryl alcohols, diols and their derivatives: complementary directed and undirected asymmetric dihydroxylation reactions”, J. Chem. Soc., Perkin Trans. 1, 1631-1643 (2002).
  28. M. Harding, R. Hodgson and A. Nelson, “Sequential kinetic resolution of C2-symmetric compounds as a key step in two-directional synthesis: Structural requirements for efficient resolution of difuryl diols”, J. Chem. Soc., Perkin Trans. 1, 2403-2413 (2002).
  29. V. Suryanti, A. Nelson and A. Berry, "Cloning, over-expression, purification and chacterisation of N-acetylneuraminate synthase from Streptococcus agalactiae", Protein expression and purification, 27, 346-356 (2003).
  30. J. M. Holland, M. Lewis and A. Nelson, "Desymmetrisation of a Centrosymmetric Diepoxide: Efficient Synthesis of a Key Intermediate in a Total Synthesis of Hemibrevetoxin B", J. Org. Chem., 68, 747-753 (2003).
  31. M. Harding, R. Hodgson, T. Majid, K. J. McDowall and A. Nelson, “A stereodivergent, two-directional synthesis of stereoisomeric C-linked disaccharide mimetics”, Org. Biomol. Chem., 1,  338-349 (2003).
  32. A. Berry, S. Domann, A. Nelson and G. Williams, “Modifying the stereochemistry of an enzyme-catalysed reaction by directed evolution”, Proc. Natl. Acad. Sci. USA 100, 3143-3148 (2003).
  33. C. Carter, S. Fletcher and A. Nelson, “Towards phase-transfer catalysts with a chiral anion: Inducing asymmetry in the reactions of cations”, Tetrahedron: Asymmetry 14, 1995-2004, (2003).
  34. S.Bartlett, R.Hodgson, J.M.Holland, M.Jones, C.Kilner, A.Nelson and S.Warriner, “Exploiting predisposition in the stereoselective synthesis of mono-, bi- and tetracyclic oxygen heterocycles: Equilibration between, and trapping of, alternative di- and tetraacetals”, Org. Biomol. Chem., 1, 2393-2402, (2003).
  35. “Beyond breaking the mirror plane: The desymmetrisation of centrosymmetric molecules as an efficient strategy for asymmetric synthesis”, M. Anstiss, J. M. Holland, A. Nelson and J. R. Titchmarsh, Synlett 2003, 1213-1220.
  36. C. Carter and A. Nelson, “Asymmetric phase transfer catalysis”, eds. H.-G. Schmaltz and T. Wirth, in Organic Synthesis Highlights V, p. 125-133, Weinheim, Wiley, (2003).
  37. A. Nelson, “3-Oxidopyrylium salts and their thio and benzo-fused analogues”, ed. E. J. Thomas, in Science of Synthesis, vol. 14, Stuttgart, Thieme, p. 639-647, (2003).
  38. A. Nelson, “Benzothiopyranones”, ed. E. J. Thomas, in Science of Synthesis, vol. 14, Stuttgart, Thieme, p. 787-816, (2003).
  39. R. Hodgson and A. Nelson, “A two-directional synthesis of the C58-C71 fragment of palytoxin”, Org. Biomol. Chem., 2, 373-386, (2004).
  40. S. Bartlett and A. Nelson, “Towards configurationally stable bisindolylmaleimide cyclophanes: Potential tools for investigating protein kinase function”, Chem. Commun. 1112-1113, (2004).
  41. A. Kennedy, A. Nelson and A. Perry, “Highly diastereoselective addition of ketone enolates to N-sulfinyl imines: Asymmetric synthesis of syn- and anti-1,3-amino alcohol derivatives”, Synlett 967-970, (2004).
  42. S. Bartlett and A. Nelson, “Evaluation of alternative approaches for the synthesis of macrocyclic bisindolylmaleimides”, Org. Biomol. Chem., 2, 2874-2883, (2004).
  43. A. Nelson, "The development of strategies and methods for the synthesis of biologically active compounds", New J. Chem. 2004, 28, 771-776.
  44. A. Berry, A. Nelson and G. J. Williams, “Directed Evolution of Enzymes for Biocatalysis and the Life Sciences”, Cell. Mol. Life Sci. 2004, 61, 3034-3046.
  45. A. Nelson, “Ynones”, eds. J. Cossy and E. J. Thomas, in Science of Synthesis, vol. 26, Stuttgart Thieme, (2004).
  46. A. Kennedy, A. Perry and A. Nelson, “A general, two-directional synthesis of aza-(1®1’)-C-disaccharide mimetics”, Chem. Commun., 2005, 1646-1648.
  47. T. Woodhall, G. Williams, A. Berry and A. Nelson, “Synthesis of screening substrates for the directed evolution of sialic acid aldolase: Towards tailored enzymes for the preparation of influenza A sialidase inhibitor analogues”, Org. Biomol. Chem.2005, 3, 1795-1800.
  48. T. Woodhall, G. Williams, A. Berry and A. Nelson, “Creation of an aldolase for the parallel synthesis of sialic acid mimetics”, Angew. Chem., Int. Ed., 2005, 44, 2109-2112.
  49. G. J. Williams, T. Woodhall, A. Nelson and A. Berry, “Structure-guided saturation mutagenesis of N-acetylneuraminic acid lyase for the synthesis sialic acid mimetics”, Prot. Eng. Des. Sel. 2005, 18, 239-246.
  50. A. Ironmonger, P. Stockley and A. Nelson, “Asymmetric double ring-opening of a C2h-symmetric bisepoxide: Improved enantiomeric excess of the product through enantioselective desymmetrisation and ‘proof-reading’ steps”, Org. Biomol. Chem., 2005, 3, 2350-2353.
  51. B. Clique, A. Ironmonger, B. Whittaker, J. Colley, J. Titchmarsh, P. Stockley and A. Nelson, “Synthesis of a library of stereo- and regiochemically diverse aminoglycoside derivatives”, Org. Biomol. Chem., 2005, 3, 2776-2785.
  52. S. Barrett, S. Bartlett, A. Bolt, A. Ironmonger, C. Joce, A. Nelson and T. Woodhall, “Configurational stability of bisindolylmaleimide cyclophanes: From conformers to the first configurationally stable, atropisomeric bisindolylmaleimides”, Chem. Eur. J. 2005, 11, 6274-6283.
  53. C. Cordier and A. Nelson, “Reaching the target: small molecules aim to probe barrier quality”, ChemBioChem 2005, 6, 1953-1955.
  54. S. Bartlett, G. S. Beddard, R. M. Jackson, V. Kayser, C. Kilner, A. Leach, A. Nelson, P. R. Oledzki, P. Parker, G. D. Reid and S. L. Warriner, “Comparison of the ATP binding sites of Protein Kinases using conformationally diverse bisindolylmaleimides”, J. Am. Chem. Soc. 2005, 127, 11699-11708.
  55. A. Kennedy, A. Perry and A. Nelson, “Methods for the synthesis of polyhydroxylated piperidines by diastereoselective dihydroxylation: Exploitation in the two-directional synthesis of aza-C-linked disaccharide derivatives”, Beilstein J. Org. Chem. 2005, 1, 2.
  56. A. N. Bullock, J. É. Debreczini, O. Y. Fedorov, A. Nelson, B. Marsden and S. Knapp, “Structural basis of inhibitor specificity of the human proto-oncagene proviral insertion site in Moloney Murine Leukaemia Virus (PIM-1) kinase”, J. Med. Chem. 2005, 48, 7604-7614.
  57. A. Nelson, “Building bridges between Chemistry and Biology”, Chemical Biology Forum Newsletter, 2005.
  58. C. Crawford, A. Nelson and I. Patel, “Development of an Approach to the Synthesis of the ABC Ring System of Hemibrevetoxin B”, Org. Lett. 2006, 8, 4231-4234.
  59. M. Anstiss and A. Nelson, “Catalytic and stoichiometric approaches to the desymmetrisation of centrosymmetric piperazines by enantioselective acylation: A total synthesis of Dragmacidin A”, Org. Biomol. Chem. 2006, 4, 4135-4143.
  60. G. J. Williams, T. Woodhall, L. Farnsworth, A. Nelson and A. Berry, “Creation of a Pair of Stereochemically Complementary Biocatalysts”, J. Am. Chem. Soc. 2006, 128, 16238-16247.
  61. M. P. Storm, H. K. Bone, C. G. Beck, P.-Y. Bourillot, V. Schreiber, T. Damiano, A. Nelson, P. Savatier and M. J. Welham, “Regulation of Nanog expression by phosphoinositide 3-kinase-dependent signalling in murine embryonic stem cells”, J. Biol. Chem. 2007, 282, 6265-6273.
  62. A. Ironmonger, B. Whittaker, A. J. Baron, B. Clique, C. J. Adams, A. E. Ashcroft, P. G. Stockley and A. Nelson, “Scanning conformational space with a library of stereo- and regiochemically diverse aminoglycoside derivatives: The discovery of new ligands for RNA hairpin sequences”, Org. Biomol. Chem. 2007, 5, 1081-1086.
  63. R. Hodgson, A. Kennedy, A. Nelson and A. Perry, “Synthesis of 3-sulfonyloxypyridines: Oxidative ring expansion of α-furylsulfonamides and N→O sulfonyl transfer”, Synlett 2007, 1043-1046.
  64. K. Dodd, D. Morton, S. Worden, R. Narquizian and A. Nelson, “Desymmetrisation of a Centrosymmetric Molecule by Carbon-Carbon Bond Formation: Asymmetric Aldol Reactions of a Centrosymmetric Dialdehyde”, Chem. Eur. J. 2007, 13, 5857-5861.
  65. C. Cordier, S. Leach and A. Nelson, “1,3-Dioxetanes and 1,3-Dioxolanes”, ed. S. Warriner, in Science of Synthesis, vol. 29, Stuttgart Thieme, (2007), pp 407-486.
  66. T. Damiano, D. Morton and A. Nelson, “Photochemical transformations of pyridinium salts: mechanistic studies and applications in synthesis”, Org. Biomol. Chem. 2007, 5, 2735-2752.
  67. A. Bolt, A. Berry and A. Nelson, “Directed evolution of aldolases for exploitation in synthetic organic chemistry”, Arch. Biochem. Biophys. 2008, 474, 318-330.
  68. S. G. Leach, C. J. Cordier, D. Morton, G. J. McKiernan, S. Warriner and A. Nelson, “A fluorous-tagged linker from which small molecules are released by ring-closing metathesis”, J. Org. Chem. 2008, 73, 2752-2759.
  69. C. Cordier, D. Morton, S. Murrison, A. Nelson and C. O’Leary-Steele, “Natural products as an inspiration in the diversity-oriented synthesis of bioactive compound libraries”, Nat. Prod. Rep. 2008, 719-737.
  70. C. Cordier, D. Morton, S. Leach, T. Woodhall, C. O’Leary-Steele, S. Warriner and A. Nelson, “An efficient method for synthesising unsymmetrical silaketals: substrates for ring-closing, including macrocycle-closing, metathesis”, Org. Biomol. Chem. 2008, 6, 1734-1737
  71. J.  Horn, S.  Marsden, A.  Nelson, D.  House and G.  Weingarten , “Convergent, Regiospecific Synthesis of Quinolines from o-Aminophenylboronates” , Org. Lett. 2008, 4117-4120
  72. D. Morton, S. Leach, C. Cordier, S. Warriner and A. Nelson, “Synthesis of natural product-like molecules with over eighty distinct skeletons”, Angew. Chem., Int. Ed. 2009, 47, 104-109. This paper has been featured in News and Views articles (S. Schreiber, Nature 2009, 457, 153-154; H. Waldmann, Nature Chem. Biol. 2009, 5, 76-77; D. Spring et al, Angew. Chemie. Int. Ed.  2009, 47, 1194-1196).  In addition, the paper was selected by the editors of Science as a highlight of the recent literature (Science 2009, 323, 16) and was a research highlight in Chemical and Engineering News and Nature Chemistry.
  73. H. K. Bone, T. Damiano, S. Bartlett, A. Perry, J. Letchford, A. Nelson and M. J. Welham “Involvement of glycogen synthase kinase-3 in regulation of murine embryonic stem cell self-renewal revealed by a series of bisindolylmaleimides”, Chem. Biol. 2009, 16, 15-27.  The research has been featured by the Daily Telegraph and the London Evening Standard.  This paper was highlighted in a preview in Cell Stem Cell (Cell Stem Cell 2009, 4, 98-100).
  74. C. Joce, J. Caryl, P. G. Stockley, S. Warriner and A. Nelson, “Identification of stable S-adenosylmethionine (SAM) analogues derivatised with bioorthogonal tags: Effect of ligands on the affinity of the E. coli methionine repressor, MetJ, for its operator DNA”, Org. Biomol. Chem. 2009, 7, 635-638.
  75. S. Murrison, D. Glowacki, C. Einzinger, J. Titchmarsh, S. Bartlett, B. McKeever-Abbas, S. Warriner and A. Nelson, “Remarkably slow rotation about a single bond between an sp3-hybridised carbon and an aromatic ring without ortho substituents”, Chem. Eur. J. 2009, 15, 2185-2189.
  76. C. O’Leary-Steele, C. Cordier, J. Hayes, S. Warriner and A. Nelson, “A fluorous-tagged ‘safety catch’ linker for preparing heterocycles by ring-closing metathesis”, Org. Lett. 2009, 11, 915-918.
  1. I. Campeotto, S. B. Carr, C. H. Trinh, A. Nelson, A. Berry, S. E. V. Phillips and A. R. Pearson, Arwen R.  “Structure of an Escherichia coli N-acetyl-D-neuraminic acid lyase mutant, E192N, in complex with pyruvate at 1.45 Å resolution”, Acta Crystall. F 2009,  F65, 1088-1090.
  2. J. Horn, H. Y. Li, S. P. Marsden, A. Nelson, R. J. Shearer, A. J. Campbell, D. House and G. Weingarten, “Convergent synthesis of dihydroquinolones from o-aminoarylboronates”, Tetrahedron  2009, 65, 9002-9007.
  3. L. E. Horsfall, A. Nelson and A. Berry, “Identification and characterization of important residues in the catalytic mechanism of CMP-Neu5Ac synthetase from Neisseria meningitides”, FEBS J. 2010, 277, 2779-2790.
  4. C. O’Leary-Steele, P. J. Pedersen, T. James, T. Lanyon-Hogg, S. Leach, J. Hayes and A. Nelson, “Synthesis of Small Molecules with High Scaffold Diversity: Exploitation of Metathesis Cascades in Combination with Inter- and Intramolecular Diels-Alder Reactions”, Chem. Eur. J. 2010, 16, 9563-9671.
  5. C. T. Brain, A. Chen, A. Nelson, N. Tanikkul and E. J. Thomas, “Synthesis of macrocyclic precursors of lankacidins using Stille reactions of 4-(2-iodo-alkenyl)azetidinones and related compounds for ring closure”, Tetrahedron 2010, 66, 6613-6625.
  6. I. Campeotto, A. H. Bolt, T. A. Harman, C. Dennis, C. H. Trinh, S. E. V. Phillips, A. Nelson, A. R. Pearson and A. Berry, “Structural Insights into Substrate Specificity inVariants of N-Acetylneuraminic Acid Lyase Produced by Directed Evolution”, J. Mol. Biol. 2010, 404, 56-69.
  7. P. Tosatti, J. Horn, A. J. Campbell, D. House, A. Nelson, and S. P. Marsden, “Iridium-Catalyzed Asymmetric Allylic Amination with Polar Amines: Access to Building Blocks with Lead-Like Molecular Properties”, Adv. Synth. Catal. 2010, 352, 3153-3157.
  1. M. Fisher and A. Nelson, “The Chemical Genetic Approach: The Interrogation of Biological Mechanisms with Small Molecule Probes”, in New Frontiers in Chemical Biology: Enabling Drug Discovery, ed. M. E. Bunnage, RSC Publishing, Cambridge, 2011.
  2. S. Murrison, S. K. Mauyra, C. Einzinger, B. McKeever-Abbas, S. Warriner and A. Nelson, “Synthesis of Skeletally-Diverse Alkloid-like Small Molecules”, Eur. J. Org. Chem. 2011, 2354-2359.
  3. H. K. Bone, A. Nelson, C. E. P. Goldring, D. Tosh and M. J. Welham, “A novel chemically directed route for the generation of definitive endoderm from human embryonic stems cells based on inhibition of GSK-3”, J. Cell. Sci. 2011, 114, 1992-2000.
  4. P. Tosatti, A. J. Campbell, D. House, A. Nelson and S. P. Marsden, “Control in Sequential Asymmetric Allylic Substitution: Stereodivergent Access to N,N-Diprotected Unnatural Amino Acids”, J. Org. Chem. 2011, 76, 5495-5501.
  5. M. Dow, M. Fisher, T. James, F. Marchetti and A. Nelson, “Towards the Systematic Exploration of Chemical Space”, Org. Biomol. Chem. 2012, 10, 17-28.
  6. C. Joce, R. White, P. G. Stockley, S. Warriner, W. B. Turnbull and A. Nelson, “Design, Synthesis and In Vitro Evaluation of Novel Bivalent S-Adenosylmethionine Analogues”, Bioorg. Med. Chem. Lett. 2012, 22, 278-284.
  7. N. Timms, A. Daniels, A. Nelson and A. Berry, “Directed Evolution and (Semi-) Rational Design Strategies for the Creation of Synthetically Useful, Stereoselective Biocatalysts”, Comprehensive Chirality, ed. N. J. Turner.
  8. P. Tosatti, A. Nelson and S. P. Marsden, “Recent advances and applications of iridium-catalysed asymmetric allylic substitution”, Org. Biomol. Chem. 2012, 10, 3147-3163.
  9. A. Kinnell, T. Harman, M. Bingham, A. Berry and A. Nelson, “Development of an organo- and enzyme-catalysed one-pot, sequential three-component reaction”, Tetrahedron 2012, 68, 7719-7722.
  10. P. MacLellan and A. Nelson, “A conceptual framework for analysing and planning synthetic approaches to diverse lead-like scaffolds”, Chem. Commun. 2013, 2383-2393.
  11. M. Dow, F. Marchetti and A. Nelson, “Diversity-oriented synthesis of natural product-like libraries”, Diversity-oriented synthesis, ed. A. Trabocchi, chapter 9, pp 291-323.
  12. S. K. Maurya, M. Dow, S. Warriner and A. Nelson, "Synthesis of skeletally diverse alkaloid-like molecules: exploitation of metathesis substrates assembled from triplets of building blocks", Beil. J. Org. Chem. 2013, 9, 775-785.
  13. N. Timms, C. L. Windle, A. Polyakova, J. R. Ault, C. H. Trinh, A. R. Pearson, A. Nelson and A. Berry, “Structural insights into the recovery of aldolase activity in N-acetylneuraminic acid lyase by replacement of the catalytically active lysine with g-thialysine by using a chemical mutategenesis strategy”, ChemBioChem 2013, 14, 474-481.
  14. R. Doveston, S. Marsden and A. Nelson, “Towards the realisation of lead-oriented synthesis”, Drug Discov. Today 2013, 19, 813-819.
  15. M. Fisher, R. Basak, A. P. Kalverda, C. W. G. Fishwick, W. B. Turnbull and A. Nelson, “Discovery of novel FabF ligands inspired by platensimycin by integrating structure-based design with diversity-oriented synthetic accessibility”, Org. Biomol. Chem. 2014, 12, 486-494.
  16. T. James, I. Simpson, J. A. Grant, V. Sridharan and A. Nelson, "Modular, gold-catalysed approach to the synthesis of lead-like piperazine scaffolds", Org. Lett. 2013, 15, 6094-6097.
  17. A. Daniels, I. Campeotto, M. van der Kamp, A. Bolt, C. Trinh, S. Phillips, A. Peason, A. Nelson, A. Mulholland and A. Berry, “The reaction mechanism of N-acetylneuraminic acid lyase revealed by a combination of crystallography, QM/MM simulation and mutagenesis”, ACS Chem. Biol. 2014, 9, 1025-1032.
  18. H. L. Martin, M. Adams, J. Higgins, J. Bond, E. E. Morrison, S. M. Bell, S. Warriner, A. Nelson and D. C. Tomlinson, “High-Content, High-Throughput Screening for the Identification of Cytotoxic Compounds Based on Cell Morphology and Cell Proliferation Markers”, Plos ONE 2014, 9, e88338.
  19. C. L Windle, Marion Müller, Adam Nelson and Alan Berry, “Engineering aldolases as biocatalysts”, Curr. Opin. Chem. Biol. 2014, 19, 25-33.
  20. G. M. Burslem, H. F. Kyle, A. L. Breeze, T. A. Edwards, A. Nelson, S. L. Warriner and A. J. Wilson, “Small Molecule Proteomimetic Inhibitors of the HIF-1a/p300 Protein-Protein Interaction”, ChemBioChem 2014,14, 1083-1087.
  21. T. James,P. MacLellan, G. M. Burslem, Iain Simpson, J. Andrew Grant, Stuart Warriner, V. Sridharan and A. Nelson, “A modular lead-oriented synthesis of diverse piperazine, 1,4-diazepane and 1,5-diazocane scaffolds”, Org. Biomol. Chem. 2014, 12, 2584-2591.
  22. H.-Y. Li, J. Horn, A. Campbell, D. House, A. Nelson and S. P. Marsden, “A convergent rhodium-catalysed asymmetric synthesis of tetrahydroquinolines”, Chem. Commun. 2014, 50, 10222-10224.
  23. G. Karageorgis, S. Warriner and A. Nelson, “Efficient discovery of bioactive scaffolds by activity-directed synthesis”, Nature Chem. 2014, 6, 872-876. This paper was featured on the front cover of the October 2014 edition of Nature Chemistry.  It was featured in the editorial (Nature Chem. 2014, 6, 841), an interview (Nature Chem. 2014, 6, 845-6) and a News & Views article (Lowe; Nature Chem. 2014, 6, 851-2).  It was also featured in a themed web issue entitled “Biomimetic Drug Discovery”.
  1. P. Craven, A. Aimon, M. Dow, N. Fleury-Bregeot, R. Guilleux, R. Morgantin, D. Roche, T. Kalliokoski, R. Foster, S. P. Marsden and A. Nelson, “Design, synthesis and decoration of molecular scaffolds for exploitation in the production of alkaloid-like libraries”, Bioorg. Med. Chem. 2015, 23, 2629-2635.
  2. I. Colomer, O. Adeniji, G. M. Burslem, P. Craven, M. O. Rasmussen, A. Willaume, T. Kalliokoski, R. Foster, S. P. Marsden and A. Nelson, “Aminomethylhydroxylation of alkenes: Exploitation in the synthesis of scaffolds for small molecule libraries”, Bioorg. Med. Chem. 2015, 23, 2736-2740.
  3. R. G. Doveston, P. Tosatti, M. Dow, D. J. Foley, H. Y. Li, A. J. Campbell, D. House, I. Churcher, S. P. Marsden and A. Nelson, “A unified lead-oriented synthesis of over fifty molecular scaffolds”, Org. Biomol. Chem. 2015, 13, 859-865.
  4. A. Nelson and D. Roche, “Innovative Approaches to the Design and Synthesis of Small Molecule Libraries”, Bioorg. Med. Chem. 2015, 23, 2613.
  5. J. D. Firth, R. Zhang, R. Morgentin, R. Guilleux, T. Kalliokoski, S. Warriner, R. Foster, S. P. Marsden and A. Nelson, “Exploitation of the Ugi-Joullié reaction in the synthesis of libraries of drug-like bicyclic hydantoins”, Synthesis 2015, 47, 2391-2406.
  6. D. J. Foley, R. G. Doveston, I. Churcher, A. Nelson and S. P. Marsden, “A systematic approach to diverse, lead-like scaffolds from a,a-disubstituted amino acids”, Chem. Commun. 2015, 51, 11174-11177.
  7. H. F. Kyle, K. F. Wickson, J. Stott, G. M. Burslem, A. L. Breeze, D. C. Tomlinson, S. L. Warriner, A. Nelson, A. J. Wilson and T. A. Edwards, “Exploration of the HIF-1a/p300 binding interface using peptide and adhiron phage display technologies to locate binding hot-spots for inhibitor development”, Mol. Biosys. 2015, 11, 2738-2749.
  8. A. Karawajczyk, F. Giordanetto, J. Benningshof, D. Hamza, T. Kalliokoski, K. Pouwer, R. Morgentin, A. Nelson, G. Müller, A. Piechot and D. Tzalis, “Expansion of chemical space for collaborative lead generation and drug discovery: the European Lead Factory perspective”,, Drug Discov. Today 2015, 20, 1310-1316.
  9. G. Karageorgis, M. Dow, A. Aimon, S. Warriner and A. Nelson, “Activity-directed Synthesis with Intermolecular Reactions: Development of a Fragment into a Range of Androgen Receptor Agonists”, Angew. Chem. Int. Ed. 2015, 54, 13538-13544.
  10. J. Stockwell, A. D. Daniels, C. L. Windle, T. Harman, T. Woodhall, T. Lebl, C. H. Trinh, K. Mullholland, A. R. Pearson, A. Berry and A. Nelson, “Evaluation of fluoropyruvate as nucleophile in reactions catalysed by N-acetyl neuraminic acid lyase variants: scope, limitations and stereoselectivity”, Org. Biomol. Chem. 2016, 14, 105-12.
  11. C. Kallus, J. Hüser, P. S. Jones and A. Nelson, “The European Lead Factory”, in Small Molecule Medicinal Chemistry: Strategies and Technologies, eds. W. Czechtizky and P. Hamley, Wiley, 2015.
  12. G. M. Burslem, H. F. Kyle, A. L. Breeze, T. A. Edwards, A. Nelson, S. L. Warriner and A. J. Wilson, “Towards ‘bionic’ proteins: replacement of continuous sequences from HIF-1a with proteomimetics to create functional p300 binding HIF-1a mimics”, Chem. Commun. 2016, 52, 5421-5424.
  13. G. M. Burslem, H. F. Kyle, P. Prabhakaran, A. L. Breeze, T. A. Edwards, S. L. Warriner, A. Nelson and A. J. Wilson, “Synthesis of highly functionalised oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups”, Org. Biomol. Chem. 2016, 14, 3782-3786.
  14. J. K. Howard, M. Müller, A. Berry and A Nelson, “An enantio- and diastereoselective chemoenzymatic synthesis of a-fluoro b-hydroxy carboxylic esters”, Angew. Chem. Int. Ed. 2016, 55, 6767-6770.
  15. I Colomer, C. J. Empson, P. Craven, Z. Owen, R. G. Doveston, I. Churcher, S. P. Marsden and A. Nelson, “A divergent synthetic approach to diverse molecular scaffolds: assessment of lead-likeness using LLAMA, an open access computational tool”, Chem. Commun. 2016, 52, 5209-5212.
  16. J. D. Firth, P. G. E. Craven, M. Lilburn, A. Pahl, S. P. Marsden and A. Nelson, “A Biosynthesis-Inspired Approach to over Twenty Diverse Natural Product-Like Scaffolds”, Chem. Commun. 2016, 52, 9837-9840.
  17. D. J. Foley, A. Nelson and S. P. Marsden, “Evaluating New Chemistry to Drive Molecular Discovery: Fit for Purpose?”, Angew. Chem. Int. Ed. 2016, 55, 13650-13657.
  18. C. L. Windle, A. Berry and A. Nelson, “Aldolase-catalysed stereoselective synthesis of fluorinated small molecules”, Curr. Opin. Chem. Biol. 2017, 37, 33-38.
  19. J. Mayol Llinas, A. Ayscough, A. Nelson and W. Farnaby, “Assessing molecular scaffolds for CNS drug discovery”, Drug Discov. Today, 2017, 22, 965-969.
  20. C. L. Windle, K. J. Simmons, J. R. Ault, C. H. Trinh, A. Nelson, A. R. Pearson and A. Berry, “Extending enzyme molecular recognition with an expanded amino acid alphabet”, Proc. Natl. Acad. Sci. USA 2017, 114, 2610-2615.
  21. S. Y. Chow and A. Nelson, “Embarking on a Chemical Space Odyssey”, J. Med. Chem. 2017, 60, 3591-3593.
  22. M. Dow, F. Marchetti, K. A. Abrahams, L. Vaz, G. S. Besra, S. Warriner and A. Nelson, “Modular Synthesis of Diverse Natural Product-like Macrocycles: Discovery of Hits with Antimycobacterial Activity”, Chem. Eur. J. 2017, 23, 7207-7211.
  23. G. M. Burslem, H. F. Kyle, A. Nelson, T. A. Edwards and A. J. Wilson, “Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions”, Chem. Sci. 2017, 8, 4188-4202.
  24. F. Giordanetto, P. Jones, A. Nelson, J. Benningshof, G. Müller, A. Pannifer, S. van Boeckel and D. Tzalis, “European Lead Factory” in S. Chackalamannil, D. P. Rotella and S. E. Ward, (eds.) Comprehensive Medicinal Chemistry III vol. 1, pp. 505–519. Oxford: Elsevier.
  25. D. J. Foley, P. G. E. Craven, P. M. Collins, R. G. Doveston, A. Aimon, R. Talon, I. Churcher, F. von Delft, S. P. Marsden and A. Nelson, “Synthesis and Demonstration of the Biological Relevance of sp3-rich Scaffolds Distantly Related to Natural Product Frameworks”, Chem. Eur. J. 2017, 23, 15227-15232.
  26. T. James and A. Nelson, “Fluoropyruvic Acid”, Encyclopedia of Reagents for Organic Synthesis 2018, DOI: 10.1002/047084289X.rn02168.
  27. J. Mayol-Llinas, W. Farnaby and A. Nelson, “Modular synthesis of thirty lead-like scaffolds suitable for CNS drug discovery”, Chem. Comm. 2017, 53, 12345-12348.
  28. H. Hassan, S. P. Marsden and A. Nelson, “Design and synthesis of a fragment set based on twisted bicyclic lactams”, Bioorg. Med. Chem. 2018, 26, 3030-3033.
  29. A. Aimon, G. Karageorgis, J. Masters, M. Dow, P. G. E. Craven, M. Ohsten, A. Willaume, Rémy Morgentin, N. Ruiz-Llamas, H. Lemoine, T. Kalliokoski, A. J. Eatherton, D. J. Foley, S. P. Marsden and A. Nelson, “Realisation of small molecule libraries based on frameworks distantly related to natural products”, Org. Biomol. Chem. 2018, 16, 3160-3167.
  30. R Morgentin, M. Dow, A. Aimon, G. Karageorgis, T. Kalliokoski, D. Roche, S. Marsden and A. Nelson, “Translation of innovative chemistry into screening libraries: an exemplar partnership from the European Lead Factory”, Drug Discov. Today 2018, 23, 1578-1583.
  31. S. Chow, S. Liver and A. Nelson, “Streamlining bioactive molecular discovery through integration and automation”, Nat. Rev. Chem. 2018, 2, 174-183.
  32. ed. N. J. Westwood and A. Nelson, “Chemical and Biological Synthesis: Enabling Approaches for Understanding Biology”, Royal Society of Chemistry, 2018, ISBN: 978-1-78262-948-1.
  33. N. Westwood and A. Nelson, “Synthetic Tools for Elucidating Biological Mechanisms”, DOI: 10.1039/9781788012805-00001, in Chemical and Biological Synthesis, ed. N. J. Westwood and A. Nelson, Royal Society of Chemistry, 2018, pp 1-7.
  34. S. Liver, J. Masters and A. Nelson, “Function-driven Discovery of Bioactive Small Molecules”, DOI: 10.1039/9781788012805-00138, in Chemical and Biological Synthesis, ed. N. J. Westwood and A. Nelson, Royal Society of Chemistry, 2018, pp 138-152.
  35. J. Mayol-Llinas, S. Chow and A. Nelson, “Expansion of the structure–activity relationships of BACE1 inhibitors by harnessing diverse building blocks prepared using a unified synthetic approach”, ChemMedChem 2019, 10, 616-620.
  36. R. Zhang, P. J. McIntyre, P. M. Collins, D. J. Foley, C. Arter, F. von Delft, R. Bayliss, S. Warriner and A. Nelson, “Construction of a Shape‐Diverse Fragment Set: Design, Synthesis and Screen against Aurora‐A Kinase”, Chem. Eur. J. 2019, 25, 6831-6839.
  37. A. Nelson, “Catalytic machinery of enzymes expanded”, Nature 2019, 570, 172-173.
  38. S. Rice, D. J. Cox, S. P, Marsden and A. Nelson, “Unified synthesis of diverse building blocks for application in the discovery of bioactive small molecules”, Tetrahedron 2019, 38, 130513-130520.
  39. A. A. Ibarra, G. J. Bartlett, Z. Hegedüs, S. Dutt, F. Hobor, K. A. Horner, K. Hetherington, K. Spence, A. Nelson, T. A. Edwards, D. N. Woolfson, R. B. Sessions and A. J. Wilson, “Predicting and Experimentally Validating Hot-Spot Residues at Protein–Protein Interfaces”, ACS Chem. Biol. 2019, 14, 2252–2263.
  40. S. Chow, A. I. Green, C. Arter, S. Liver, A. Leggott, L. Trask, G. Karageorgis, S. Warriner and A. Nelson, “Efficient approaches for the synthesis of diverse alpha-diazo amides”, Synthesis 2020, 52, 1695-1706.
  41. A. Gomm and A. Nelson, “A radical approach to diverse meroterpenoids”, Nature Chem. 2020, 12, 109-111.
  42. R. A. Lowe, D. Taylor, K. Chibale, A. Nelson and S. P. Marsden, “Synthesis and evaluation of the performance of a small molecule library based on diverse tropane-related scaffolds”, Bioorg. Med. Chem. 2020, 28, 115442.
  43. K. Hetherington, Z. Hegedus, T. A Edwards, R. Sessions, A. Nelson and A. J. Wilson, “Stapled Peptides as HIF‐1α/p300 Inhibitors: Helicity Enhancement in the Bound State Increases Inhibitory Potency”, Chem. Eur. J. 2020, 26, 7638-7646.
  44. A. I. Green, F. Hobor, C. P. Tinworth, S. Warriner, A. J. Wilson and A. Nelson, “Activity-directed synthesis of inhibitors of the p53/hDM2 protein-protein interaction”, Chem. Eur. J. 2020, 26, 10682-10689.
  45. A. Leggott, J. E. Clarke, S. Chow, S. L. Warriner, A. J. O’Neill* and A. Nelson, “Activity-directed expansion of a series of antibacterial agents”, Chem. Commun. 2020, 56, 8047-8050.
  46. A. F. Trindade, E. L. Faulkner, A. G. Leach, A. Nelson* and S. P. Marsden,* “Fragment-Oriented Synthesis: b-Elaboration of Cyclic Amine Fragments using Enecarbamates as Platform Intermediates”, Chem. Commun. 2020, 56, 8802-8805.
  47. G. Karageorgis, S. Liver and A. Nelson,* “Activity-directed synthesis: A flexible approach for lead generation”, ChemMedChem 2020, 15, 1776-1782.
  48. D. Francis, A. Nelson and S. P, Marsden, "Synthesis of β-Diamine Building Blocks by Photocatalytic Hydroamination of Enecarbamates with Amines, Ammonia and N-H Heterocycles", Chem. Eur. J. 2020, 26, 14861-14865.
  1. V. K. Aggarwal, S. K. Armstrong, L. Caggiano, K. Chibale, J. Clayden, I. Coldham, N. Greeves, R. C. Hartley, J. G. Knight, N. Kuhnert, H. J. Mitchell, A. Nelson, P. O’Brien, S. P. Thomas and P. Wyatt, “Obituary: Stuart Warren (24 Dec 1938–22 Mar 2020)”, Org. Biomol. Chem. 2020, 18, 7236-7237.
  2. A. I. Green, C. P. Tinworth, S. Warriner, A. Nelson* and N. Fey,* “Computational Mapping of Dirhodium(II) Catalysts”, Chem. Eur. J. 2020, 27, 2402-2409.
  3. A. Nelson and G. Karageorgis,* “Natural Product-informed exploration of chemical space to enable bioactive molecular discovery”, RSC Med. Chem. 2021, 12, 353-362.
  4. S. Rice, D. J. Cox, S. P, Marsden* and A. Nelson,* “Efficient unified synthesis of diverse bridged polycyclic scaffolds using a complexity-generating ‘stitching’ annulation approach”, Chem. Commun. 2021, 57, 599-602.
  5. “Regioselective side-chain amination of 2-alkyl azacycles by radical translocation: total synthesis of tetraponerine T8”, S. D. Griggs, A. Martin-Roncero, A. Nelson* and S. P. Marsden, Chem. Commun. 2021, 57, 919-922.
  6. “Query-guided protein-protein interaction inhibitor discovery”, S. Celis, F. Hobor, T. James, G. J. Bartlett, A. A. Ibarra, D. K. Shoemark, Z. Hegedus, K. Hetherington, D. N. Woolfson, R. B. Sessions, T. A. Edwards, D. M. Andrews,* A. Nelson* and A. J. Wilson,* Chem. Sci. 2021, 12, 4753-4762.
  7. “Towards Optimizing Peptide-Based Inhibitors of Protein-Protein Interactions: Predictive Saturation Variation Scanning (PreSaVS)”, K. Hetherington, S. Dutt, A. A. Ibarra, E. Cawood, F. Hobor, D. N. Woolfson, T. A. Edwards, A. Nelson, R. B. Sessions,* A. J. Wilson,* RSC Chem. Biol. 2021, in press.
  8. “IMI European Lead Factory — democratizing access to high-throughput screening”, P. S. Jones, S. Boucharens, S. P. McElroy, A. Morrison, S. Honarnejad, S. van Boeckel, H. van den Hurk, D. Basting, J. Hüser, S. Jaroch, E. Ottow, J. Benningshof, R. H. A. Folmer, F. Leemhuis, P. M. Kramer-Verhulst, V. J. M. Nies, K. M. Orrling, T. Rijnders, C. Pfander, O. Engkvist, G. Pairaudeau, P. B. Simpson, J.-Y. Ortholand, D. Roche, A. Dömling, S. M. Kühnert, P. W. M. Roevens, H. van Vlijmen, E. J. A. van Wanrooij, C. Verbruggen, P. Nussbaumer, H. Ovaa, M. van der Stelt, K. Baek Simonsen, L. Tagmose, H. Waldmann, J. Duffy, D. Finsinger, M. Jurzak, N. A. Burgess-Brown, W. H. Lee, F. P. J. T. Rutjes, H. Haag, C. Kallus, H. Mors, T. Dorval, B. Lesur, F. R. Olayo, D. Hamza, G. Jones, C. Pearce, A. Piechot, D. Tzalis, M. H. Clausen, J. Davis, D. Derouane, C. Vermeiren, M. Kaiser, R. A. Stockman, D. V. Barrault, A. D. Pannifer, J. R. Swedlow, A. Nelson, R. V. A. Orru, E. Ruijter, S. P. van Helden, V. M. Li, T. Vries and J. S. B. de Vlieger, Nat. Rev. Drug Discov. 2022, DOI: doi: 10.1038/d41573-021-00196-3.
  9. “A unified “top-down” approach for the synthesis of diverse lead-like molecular scaffolds”, C. Townley, L. McMurray, S. Marsden and A. Nelson, Bioorg. Med. Chem. Lett. 2022, 62, 128631.
  10. “Discovery of photocatalytic reactions enabled by high-throughput experimentation”, S. Griggs, G. Bonney, S. Liver, S. Marsden and A. Nelson, ChemRxiv DOI: 10.26434/chemrxiv-2022-pgh1w
  11. “Morphological Subprofile Analysis for Bioactivity Annotation of Small Molecules”, A. Pahl, B. Schölermann, M. Rusch, M. Dow, C. Hedberg, A. Nelson, S. Sievers, H. Waldmann and S. Ziegler, Cell Chem. Biol. 2023, 30, 839-853.E7 (previously published as: BioRxiv DOI: 10.1101/2022.08.15.503944).
  12. “Identification of Dihydroorotate Dehydrogenase Inhibitors using the Cell Painting Assay”, B. Schölermann, J. Bonowski, M. Grigalunas, A. Burhop, Y. Xie, J. G. F. Hoock, J. Liu, M. Dow, A. Nelson, C. Nowak, A. Pahl, S. Sievers and S. Ziegler, ChemBioChem 2022, 23, e202200475.
  13. “Algorithm-driven activity-directed expansion of a series of antibacterial quinazolinones”, D. Francis, S. Farooque, A. Meager, D. Dirks, A. Leggott, S. Warriner, A. J. O’Neill and A. Nelson, Org. Biomol. Chem. 2022, 20, 9672-9678.
  14. “Synthesis of Spirocyclic            1,2-Diamines        by           Dearomatising      Intramolecular Diamination              of       Phenols”, A. Aimon, M. Dow, A. R. Hanby, E. Okolo, C. M. Pask, A. Nelson and S. P. Marsden, Chem. Commun., 2023, 59, 607-610.
  15. “Scaffold Remodelling of Diazaspirotricycles Enables Synthesis of Diverse sp3-Rich Compounds With Distinct Phenotypic Effects”, E. Okolo, A. Pahl, S. Sievers, C. Pask, A. Nelson and S. Marsden, Chem. Eur. J. 2023, 26, e202203992 (previously published as: ChemRxiv 2022, DOI: 10.26434/chemrxiv-2022-d7kn9)
  16. “Modular Synthesis of Bicyclic Twisted Amides and Anilines”, A. Hindle, K. Baj, J. A. Iggo, D. J. Cox, C. M. Pask, A. Nelson and S. P. Marsden, Chem. Commun., 2023, 59, 6239-6242 (previously published as: ChemRxiv 2023, DOI: 10.26434/chemrxiv-2023-g1b0d)